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The Myth About
Conjugation with glucuronic acid is one of the major detoxification mechanisms in mammalian species for a variety of foreign and endogenous compounds. This process is catalyzed by endoplasmic reticulum-bound UDP-glucuronosyltransferases. When it became evident that what was identified as Glucuronic acid , was instead 2-keto-Gluconic acid, our investigation became focused on determining what was in solution that could be the reason behind Kombucha's claimed improvements to the consumerís health. (Report on Growers - An Analysis of the Kombucha Ferment).
The two images on this page will provide those interested in this topic of a way to visualize how one determines the particular types of chemical compounds in a complex mixture like Kombucha. The image on the top contains chemical standards for Glucuronic acid, 2-keto-Gluconic acid, Gluconic acid, and Fructose. The image on the bottom contrasts these chemical standards against the very popular ProNatura bottled Kombucha ferment.
It may be that the peak was originally identified as Glucuronic acid, because of the increased numbers of glucuronides in the urine of Kombucha drinkers. The theory being that an increase in glucuronides would be consistent with an increase in Glucuronic acid. There is another possible explanation for the increased glurcuronides in the urine of Kombucha drinkers ... the possible presence in Kombucha of a potent beta-glucuronidase inhibitor. Each Glucuronic acid molecule that forms a glucuronide with a toxin in the body is a one to one relationship (one Glucuronic acid molecule bound to one toxic molecule). Glucuronidase enzymes cleave the bond between the two molecules, but do not become bound themselves. A single glucuronidase enzyme can cleave hundreds of glucuronides. The presence of the beta-glucuronidase inhibitor, Saccharic acid 1,4-lactone, even in micro quantities can prevent the glucuronidase enzyme from cleaving the bound glucuronides.